A plain-English guide to the coenzyme behind the biggest trend in longevity medicine — what it does, why it matters, and how it's actually administered.
NAD+ stands for nicotinamide adenine dinucleotide, a coenzyme found in every living cell. Think of it as a shuttle that carries electrons between molecules during metabolism — without it, your cells can't convert the food you eat into ATP, the energy currency your body runs on.
Beyond energy production, NAD+ also plays a key role in DNA repair and activating sirtuins, a family of proteins linked to cellular aging and stress resistance. That dual role — powering metabolism and supporting repair — is why researchers and clinicians have taken a growing interest in it over the past decade.
Research shows NAD+ concentrations in human tissue drop substantially between young adulthood and older age. A few things drive this decline: increased activity of enzymes that consume NAD+ as we age, chronic low-grade inflammation, and simply reduced cellular efficiency over time.
Lower NAD+ availability has been associated with reduced mitochondrial function, slower cellular repair, and the general sense of lower energy many people notice as they get older. This is the biological rationale behind NAD+ supplementation and IV therapy.
NAD+ is a large, fragile molecule that breaks down significantly when it passes through the digestive system. Oral NAD+ precursors like NMN or NR are popular, but they rely on your body converting them into NAD+ internally — a process that varies a lot from person to person.
Intravenous administration delivers NAD+ directly into the bloodstream, avoiding the digestive breakdown entirely. This is the main reason IV NAD+ therapy has become the preferred route for people seeking a more direct, provider-monitored approach.
At IVs For Me, NAD+ is offered in 250mg, 500mg, 750mg, and 1,000mg doses, with your provider helping you choose based on your goals and prior experience with the treatment.
Many people describe a warm or tingling sensation, particularly in the face or chest, as the infusion runs — this is normal and typically subsides when the rate is slowed.
People generally come to NAD+ IV therapy for one of three reasons: general longevity and cellular health support, recovery from periods of high stress or poor sleep, or as part of a broader wellness or performance routine alongside peptide therapy or medical weight loss.
Book a visit and your provider will walk you through dosing options.
Book your first visit and a licensed provider will help you choose the right dose.
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